MEDICAL DESCRIPTION OF FORSTAVIR L TABLET
 
Forstavir L contains Lamivudine 300mg and Tenofovir disoproxil fumarate 300mg. Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is an antiviral medicine used in the treatment of Human Immunodeficiency Virus (HIV)-1 infection. Forstavir L tablet is a nucleoside analogue. Forstavir L tablet acts on HIV reverse transcriptase thus interferes with their reproduction cycle.
 
 
FORSTAVIR L TABLET USES
 
Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is used to treat adults and adolescence above 18 years of age who are infected by HIV. Forstavir L tablet is used in caution with hepatitis B and renal impairment.
 
 
FORSTAVIR L TABLET BENEFITS
 
Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet helps to decrease the amount of HIV virus in your body thus your immunity works better by reducing your chance of getting HIV complications like co-infections and other cancers. Forstavir L tablet is not a cure for HIV infection, it improves immunity that results in longevity of life; thus, precautions are necessary while sexual intercourse, surgery etc. Forstavir L tablet is safely used in adolescence above age 18 and adults
 
 
FORSTAVIR L TABLET INDICATION
 
Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is indicated in the treatment of HIV infection that causes AIDS in humans. Forstavir L tablet is used to boost the immunity of the affected hosts by reducing the viral load of the infected cells. Prior to administration of Forstavir L tablet screening for hepatitis B infection and renal impairment is noted. Forstavir L tablet causes flare up of hepatitis B infection and end-stage renal failure. Forstavir L tablet is indicated in ages above 18 years.
 
 
MECHANISM OF ACTION OF FORSTAVIR L TABLET
 
Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is a nucleoside analogue that acts as a reverse transcriptase inhibitor. Tenofovir disoproxil fumarate present in Forstavir L tablet is an analogue of adenosine 5-monophosphate which is converted to tenofovir after hydrolysis after which tenofovir inhibits HIV-1 reverse transcriptase. Tenofovir competes with AMP as a substrate and competes to incorporate themselves into the DNA strand thus stops the replication of viral particles.  Lamivudine present in Forstavir L tablet is an analogue that is phosphorylated to its active forms lamivudine triphosphate that incorporated into the nucleotide and inhibits the action of HIV-1 reverse transcriptase. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.
 
 
HOW FORSTAVIR L TABLET WORKS
 
Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is a nucleoside analogue that acts as reverse transcriptase inhibitor. The active substance of tenofovir disoproxil fumarate and lamivudine competes with AMP and incorporates themselves into DNA strand and thus replication process of viral particle is terminated. Thus, the active HIV molecule becomes inactive and further reproduction and multiplication process is stopped.
 
 
FORSTAVIR L TABLET CONTRAINDICATION
 
if you are allergic to Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet and its contents
if you have a liver disease like hepatitis B or C or hepatomegaly with steatosis
if you have kidney impairment
if <18 years of age
if you are breastfeeding
if you are pregnant
 
 
FORSTAVIR L TABLET SIDE EFFECTS
 
Common side effects that occur 1:10 patients: Headache, insomnia, Cough, Nausea, vomiting, abdominal pain or cramps, diarrhoea, Rash, alopecia, Arthralgia, Fatigue, malaise, fever, hypophosphataemia, asthenia
Uncommon side effects that occur 1:100 patients: Neutropenia and anaemia, thrombocytopenia, hypokalaemia, proximal renal tubulopathy 
Rare side effects that occur 1:1,000 patients: Pancreatitis, Hepatitis, Angioedema, hepatic steatosis, osteomalacia, acute renal failure, renal failure, acute tubular necrosis, nephritis 2, nephrogenic diabetes insipidus,  
Very rare side effects that occur 1:10,000 patients: Pure red cell aplasia, Lactic acidosis, Peripheral neuropathy, Rhabdomyolysis
 
 
FAQS FOR FORSTAVIR L TABLET
 
Is Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet safe during pregnancy?
This medication is used with caution in pregnancy when pros outweigh the cons. Consult your physician.
Can Forstavir L tablet be taken while breastfeeding?
There is no specific study to detail this. But in general HIV virions can pass via breastfeeding thus it is suspected that antivirals can also pass via breastfeeding. Thus, consult your physician.
Can Forstavir L tablet be taken while alcohol consumption?
The interaction is unknown but this medication causes dizziness. Thus, consult your physician.
Can I take drive or operate heavy machineries while on Forstavir L tablet?
This medication causes dizziness and instability thus caution is used while driving or operating machineries.
Can Forstavir L tablet be taken in case of hepatitis B?
No, Forstavir L tablet must be taken when diagnosed with hepatitis B as this medication may cause failure
 
 
PRECAUTIONS AND GENERAL WARNING OF FORSTAVIR L TABLET
ALCOHOL
 
Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet generally causes side effects thus it is advised not to be taken with alcohol. For further queries, consult your physician.
 
DRIVING OR OPERATING MACHINERY
 
It is preferred to drive or operate heavy machinery with caution as Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet causes side effects. For further queries, consult your physician.
 
PREGNANCY
 
Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is cautiously used during pregnancy as it may cause some side effects on the fetus. Thus, consult your physician.
 
BREAST FEEDING
 
The use of Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet during breastfeeding is not recommended as evidence shows less amount of the medication passes via breastfeeding to the baby that may cause adverse effects in newborn.
 
KIDNEY PROBLEM
 
Inform your physician if you have compromised kidney function as Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet may cause renal disorders that results in end-stage kidney failure
 
LIVER DISEASE
 
Inform your physician if you have hepatitis B or C
 
 
USE OF FORSTAVIR L TABLET IN CHILDREN
 
Forstavir L (Lamivudine (300mg) + Tenofovir disoproxil fumarate (300mg)) tablet is not recommended for ages below 18.